Published: Thu, November 22, 2018
Medicine | By Daryl Nelson

Will Peanut Treatment Guard Against Peanut Allergy?

Will Peanut Treatment Guard Against Peanut Allergy?

Peanut vs peanut " We're excited about the potential to help children and adolescents with peanut allergy protect themselves against accidentally eating a food with peanut in it", says co-author Stephen Tilles, MD.

Peanut allergies are believed to be on the rise in children, but there is now no FDA-approved treatment for the potentially life-threatening condition.

"Kids go out the door every morning, and their parents worry, this is the day they'll be exposed to peanuts and potentially have a life-threatening reaction".

"Families live in fear of accidental exposure as allergic reactions can be very severe, and can even lead to death". He carried his own cupcake to school birthday parties, cultivated the habit of reading food labels, and became a grown up without tasting a Kit Kat, Twix or Three Musketeers bar which all entailed a detection of peanut as they rendered in prerequisite that process the nuts. Under medical supervision, the dose was gradually increased over the course of six months, exposing the children to higher and higher amounts of peanut protein until a dosage of 300 milligrams was reached. OFCs are considered the gold standard for testing food allergy.

"Overall household income is only associated with peanut sanitisation in children aged one to nine years", said allergist Sandy Yip, M.D., Major, USAF, lead study author and ACAAI member.

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The researchers then tested to see whether the participants could ingest a challenge dose of 600mg or more - the equivalent of approximately two whole peanut kernels - without dose-limiting symptoms.

Aimmune Therapeutics (NASDAQ:AIMT) is up 6% premarket, albeit on only 800 shares, on the heels of the publication in the New England Journal of Medicine of results from the Phase 3 PALISADE study evaluating AR101 in patients with peanut allergy. One-third of the participants were assigned to the control (placebo) group, and the remainder were given daily doses of protein powder. But the company says it would allow peanut allergy sufferers to better tolerate accidental exposure to small amounts of peanuts, such as trace amounts hidden in packaged foods. "In addition, the symptoms caused by the 100-fold higher dose at the end of study were milder than the symptoms on the lower dose at the beginning of the study".

"The hope would be to have a treatment available in the second half of 2019".

There are now no approved treatments that prevent or reduce the symptoms of any type of food allergy. Once someone stops the treatment, there is no longer a protective effect.

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