Published: Fri, March 02, 2018
Medicine | By Daryl Nelson

Are varicose veins a warning sign of potentially deadly clots?

Are varicose veins a warning sign of potentially deadly clots?

According to the National Institute for Health and Care Excellence (NICE) at least a third of the United Kingdom population have varicose veins, and women are more likely than men to develop them.

Varicose veins, usually caused by pregnancy or the effects of age weakening the blood vessels, are common.

The incidence of PE was significantly higher among participants with varicose veins (HR 0.48 versus 0.28 per 1,000 person-years in the control group). However, Chen noted that her team is now undertaking another study to better understand how those treatments could mitigate the risk of the 3 conditions.

People with varicose veins are at significant risk of developing a potentially fatal blood clot, a research by the China Medical University suggests.

"From this study, we believe that varicose veins are not merely a cosmetic or symptomatic concern", Chen said. The HR for the association of varicose veins with PE was 1.73 (95% CI 1.54-1.94) compared with the control group. They found the veins were associated with a more serious condition of deep vein thrombosis. Overall, the HR for the patients with varicose veins with PAD was 1.72 (95% CI 1.68-1.77) compared with the control group.

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What recommendations do you have for future research as a result of this work?

Important to the study design was the fact that the three endpoints were analyzed separately, i.e., if a patient with DVT later developed PE or PAD, these were counted as cases in the analysis of the other endpoint (s). This type of blood clot commonly forms in veins, with the new research becoming one of the first in the world to link varicose veins with a health issue.

Inflammation has become "increasingly recognized as a key player in the development of vascular disease, including deep venous thrombosis, pulmonary embolism, stroke and heart attack", Piazza said.

Still, the association between varicose veins and DVT was strong, he added. Furthermore, endovenous ablation provides quick recovery which in turn is expected to create demand for varicose vein treatment. But when researchers in Taiwan looked at data on more than 400,000 people.

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