Published: Wed, January 10, 2018
Medicine | By Daryl Nelson

Too much Ibuprofen linked to male infertility

Too much Ibuprofen linked to male infertility

Researchers recruited 31 healthy young men (18 to 35 years old) to take part in the study. The bad news is the ibuprofen is one of a large class of related drugs that includes aspirin, and the likelihood that other drugs will have similar effects is high.

The study provides the first evidence that long-term ibuprofen use may lead to health issues among men, and the first time that ibuprofen was shown to affect testicular health in adults.

Ibuprofen is an anti-inflammatory that's commonly used to treat fevers and pain.

They revealed that levels of luteinising hormones, which trigger testosterone production, increased during the study.

Ibuprofen has been linked to fertility problems in men.

Researchers even tested ibuprofen on "bits of human testes" collected from organ donors and saw the same result: The drug hampered testosterone output.

The decreased ratio of testosterone to LH created a hormonal imbalance called "compensated hypogonadism" in the endocrine system, which regulates and controls hormones. That works out to three ibuprofen tablets per day if you're taking a typical 200mg/tablet product.

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The research, which was published in the Proceedings of the National Academy of Sciences journal, showed that the men who took the high doses of ibuprofen developed the disorder known as compensated hypogonadism. (In culture, there are no cells to produce luteinizing hormone to compensate.) The researchers found that a number of genes involved in steroid synthesis were affected by ibuprofen.

But long-distance runners and athletes who regularly take ibuprofen during training or sports matches in order to ward off inflammation may want to keep an eye on the research. The 17 other volunteers were given a placebo pill.

The detrimental effects of daily ibuprofen were almost immediate.

In addition to limiting fertility, ibuprofen or NSAIDS, may increase the risk of heart attack or stroke.

It's also not clear whether the same hormonal effects would be seen in men taking lower doses of ibuprofen, or whether the effects are reversible, particularly in men who take ibuprofen for long periods, study co-author Bernard Jégou, director of the National Institute for Research on Environmental and Occupational Health in France, told CNN.

"The safety and efficacy of active ingredients in these products has been well documented and supported by decades of scientific study and real-world use", said Mike Tringale, a spokesman for the association, according to Fox News.

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